Associations of Leptin and Adiponectin in Irritable Bowel Syndrome Patients with Overweight and Obesity

Irritable bowel syndrome (IBS) in overweight and obese individuals is characterized by a more severe course than patients with normal weight. The purpose. To assess the level of adipokines (leptin adiponectin) blood serum, correlation these laboratory markers clinical manifestations IBS, quality life, eating habits, signs anxiety depression based on results using special questionnaire IBS. Material methods. An open cohort cross-sectional study was conducted inclusion 175 participants aged 18 to 44 years (mean age 30.06 ± 6.15 years). Group 1 included 100 or IBS 30.63 6.37 years, BMI 25.88 6.28 kg/m2). In group 1, subgroup 1A 50 people associated obesity. 1B – suffering from 2 75 without 19 43 29.31 5.81 27.80 6.20 Subgroup 2A non-IBS who were obese. 2B 25 apparently healthy participants. symptoms assessed 10-point scale. Using verified questionnaires, severity gastrointestinal symptoms, presence depression, specific anxiety, life habits assessed. Results. obesity are higher levels leptin low adiponectin weight (Mann Whitney test, p < 0.05). Adipokine correlate high cravings for sweet, fatty, starchy, salty foods. A concentration characteristic predominance constipation High abdominal pain, flatulence, poor frequent (Spirmen test 0.05, Mann Conclusion. obtained suggest significant role formation compared